Chloe (Drew Barrymore), a diamond-clad, bootie wearing Beverly Hills Chihuahua enjoys her luxurious lifestyle so much, she hardly notices Papi (George Lopez), a hilarious Chihuahua who happens to be crazy for Chloe. But when the most pampered pooch gets lost in Mexico with only a street-wise German Shepherd (Andy Garcia) to help her find her way home, Papi heads south of the border -- joining forces with a motley crew: three dogs (Placido Domingo, Luis Guzman and Eddie “Piolin” Sotelo), two humans (Piper Perabo, Manolo Cardona), a sly rat (Cheech Marin) and a nervous iguana (Paul Rodriguez) – to rescue his true love.
